Kynureninase

KYNU
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2HZP, 3E9K
Identifiers
Aliases	KYNU, KYNUU, kynureninase, VCRL2
External IDs	OMIM: 605197 MGI: 1918039 HomoloGene: 2925 GeneCards: KYNU
Gene location (Human)
Chr.	Chromosome 2 (human)
End	143,055,833 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	43,572,727 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; sperm; ; monocyte; ; liver; ; right lobe of liver; ; kidney tubule; ; mucosa of urinary bladder; ; pancreatic ductal cell; ; blood; ; placenta;
	Top expressed in
	left lobe of liver; ; yolk sac; ; spleen; ; blood; ; kidney; ; thymus; ; secondary oocyte; ; subcutaneous adipose tissue; ; duodenum; ; jejunum;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein homodimerization activity; kynureninase activity; catalytic activity; pyridoxal phosphate binding; hydrolase activity; 3-hydroxykynureninase activity;
Cellular component	cytosol; mitochondrion; cytoplasm; nucleoplasm;
Biological process	pyridine nucleotide biosynthetic process; response to vitamin B6; response to interferon-gamma; tryptophan catabolic process to acetyl-CoA; L-kynurenine catabolic process; tryptophan catabolic process; tryptophan catabolic process to kynurenine; quinolinate biosynthetic process; anthranilate metabolic process; NAD biosynthetic process; 'de novo' NAD biosynthetic process from tryptophan; human ageing;
	Sources:Amigo / QuickGO
Orthologs
	8942
	70789
	ENSG00000115919
	ENSMUSG00000026866
	Q16719
	Q9CXF0
	NM_001032998; NM_001199241; NM_003937
	NM_027552; NM_001289593; NM_001289594; NM_001398676
	NP_001028170; NP_001186170; NP_003928
	NP_001276522; NP_001276523; NP_081828; NP_001385605
	Wikidata
View/Edit Human	View/Edit Mouse

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kynureninase
kynureninase
	Crystal structure of Homo sapiens kynureninase.
Identifiers
EC no.	3.7.1.3
CAS no.	9024-78-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
PMC
Search
PMC	articles
PubMed	articles
NCBI	proteins

Kynureninase or L-Kynurenine hydrolase (KYNU) (EC 3.7.1.3) is a PLP dependent enzyme that catalyses the cleavage of kynurenine (Kyn) into anthranilic acid (Ant). It can also act on 3-hydroxykynurenine (to produce 3-hydroxyanthranilate) and some other (3-arylcarbonyl)-alanines. Humans express one kynureninase enzyme that is encoded by the KYNU gene located on chromosome 2.

KYNU is part of the pathway for the catabolism of Trp and the biosynthesis of NAD cofactors from tryptophan (Trp).

Kynureninase catalyzes the following reaction:

L-kynurenine + H₂O ↔ anthranilate + L-alanine

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