KMO (gene)

KMO
Identifiers
Aliases	KMO, dJ317G22.1, kynurenine 3-monooxygenase (kynurenine 3-hydroxylase), kynurenine 3-monooxygenase
External IDs	OMIM: 603538 MGI: 2138151 HomoloGene: 2729 GeneCards: KMO
Gene location (Human)
Chr.	Chromosome 1 (human)
End	241,595,642 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	175,489,682 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; palpebral conjunctiva; ; kidney tubule; ; glomerulus; ; metanephric glomerulus; ; placenta; ; monocyte; ; kidney; ; spleen; ; lymph node;
	Top expressed in
	left lobe of liver; ; kidney; ; proximal tubule; ; spleen; ; blood; ; yolk sac; ; bone marrow; ; Paneth cell; ; subcutaneous adipose tissue; ; thymus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	NAD(P)H oxidase H2O2-forming activity; monooxygenase activity; oxidoreductase activity; kynurenine 3-monooxygenase activity; flavin adenine dinucleotide binding; FAD binding;
Cellular component	integral component of membrane; cytosol; membrane; mitochondrial outer membrane; mitochondrion; mitochondrial membranes; extracellular space;
Biological process	pyridine nucleotide biosynthetic process; NAD biosynthetic process; response to salt stress; secondary metabolite biosynthetic process; quinolinate biosynthetic process; tryptophan catabolic process; response to lipopolysaccharide; cellular response to interleukin-1; L-kynurenine metabolic process; positive regulation of neuron death; positive regulation of glutamate secretion, neurotransmission; NAD metabolic process; kynurenine metabolic process; 'de novo' NAD biosynthetic process from tryptophan; anthranilate metabolic process; human ageing; positive regulation of glutamate secretion; kynurenic acid biosynthetic process; cellular response to lipopolysaccharide;
	Sources:Amigo / QuickGO
Orthologs
	8564
	98256
	ENSG00000117009
	ENSMUSG00000039783
	O15229
	Q91WN4
	NM_003679
	NM_133809
	NP_003670
	NP_598570
	Wikidata
View/Edit Human	View/Edit Mouse

Kynurenine 3-monooxygenase is an enzyme that in humans is encoded by the KMO gene.

Kynurenine 3-monooxygenase (KMO; EC 1.14.13.9) is an NADPH-dependent flavin monooxygenase that catalyzes the hydroxylation of the L-tryptophan metabolite L-kynurenine to form L-3-hydroxykynurenine.[supplied by OMIM] This is the first step in the degradation of Kyneurinine to Quinolinic acid. This pathway is involved in the activation of cytokine mediated changes in behavior due to inflammatory stimuli such as infections. The KMO gene is upregulated in the lung parenchyma of smokers.

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