KLF1

KLF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L2I, 2MBH, 2N23
Identifiers
Aliases	KLF1, CDAN4, EKLF, HBFQTL6, INLU, Kruppel-like factor 1 (erythroid), Kruppel like factor 1, EKLF/KLF1
External IDs	OMIM: 600599 MGI: 1342771 HomoloGene: 4785 GeneCards: KLF1
Gene location (Human)
Chr.	Chromosome 19 (human)
End	12,887,201 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	85,631,924 bp
RNA expression pattern
	Top expressed in
	spongy bone; ; bone marrow; ; blood; ; bone marrow cells; ; monocyte; ; tibialis anterior muscle; ; spleen; ; ganglionic eminence; ; amniotic fluid; ; placenta;
	Top expressed in
	spleen; ; body of femur; ; bone marrow; ; abdominal wall; ; urethra; ; female urethra; ; yolk sac; ; male urethra; ; blood; ; endocardial cushion;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; cis-regulatory region sequence-specific DNA binding; metal ion binding; nucleic acid binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm;
Biological process	positive regulation of transcription, DNA-templated; erythrocyte differentiation; cellular response to peptide; regulation of transcription, DNA-templated; transcription, DNA-templated; maternal process involved in female pregnancy; regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	10661
	16596
	ENSG00000105610
	ENSMUSG00000054191
	Q13351
	P46099
	NM_006563
	NM_010635
	NP_006554
	NP_034765
	Wikidata
View/Edit Human	View/Edit Mouse

Krueppel-like factor 1 is a protein that in humans is encoded by the KLF1 gene. The gene for KLF1 is on the human chromosome 19 and on mouse chromosome 8. Krueppel-like factor 1 is a transcription factor that is necessary for the proper maturation of erythroid (red blood) cells.

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