KIF5A

KIF5A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UXT, 4UXY, 4UY0
Identifiers
Aliases	KIF5A, D12S1889, MY050, NKHC, SPG10, kinesin family member 5A, NEIMY, ALS25
External IDs	OMIM: 602821 MGI: 109564 HomoloGene: 55861 GeneCards: KIF5A
Gene location (Human)
Chr.	Chromosome 12 (human)
End	57,586,633 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	127,099,217 bp
RNA expression pattern
	Top expressed in
	Brodmann area 9; ; cingulate gyrus; ; prefrontal cortex; ; ganglionic eminence; ; amygdala; ; nucleus accumbens; ; caudate nucleus; ; putamen; ; anterior pituitary; ; hypothalamus;
	Top expressed in
	globus pallidus; ; lateral geniculate nucleus; ; superior frontal gyrus; ; subiculum; ; lateral hypothalamus; ; pontine nuclei; ; ventral tegmental area; ; medial geniculate nucleus; ; nucleus accumbens; ; dorsal tegmental nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; microtubule motor activity; microtubule binding; protein binding; cytoskeletal motor activity; plus-end-directed microtubule motor activity; ATP binding; kinesin binding; ATPase activity;
Cellular component	cytoplasm; cytosol; membrane; kinesin complex; neuronal cell body; ciliary rootlet; perinuclear region of cytoplasm; neuron projection; microtubule; cytoskeleton; dendrite cytoplasm; synapse; axon cytoplasm;
Biological process	protein localization; cytoskeleton-dependent intracellular transport; antigen processing and presentation of exogenous peptide antigen via MHC class II; axon guidance; chemical synaptic transmission; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; vesicle-mediated transport; microtubule-based movement; anterograde dendritic transport of neurotransmitter receptor complex; synaptic vesicle transport; anterograde axonal protein transport; retrograde neuronal dense core vesicle transport;
	Sources:Amigo / QuickGO
Orthologs
	3798
	16572
	ENSG00000155980
	ENSMUSG00000074657
	Q12840
	P33175
	NM_004984; NM_001354705; NM_032624
	NM_001039000; NM_008447
	NP_004975; NP_001341634
	NP_001034089; NP_032473
	Wikidata
View/Edit Human	View/Edit Mouse

Kinesin family member 5A is a protein that in humans is encoded by the KIF5A gene. It is part of the kinesin family of motor proteins.

This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multi-subunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this gene cause autosomal dominant spastic paraplegia 10.

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