KCNJ8

KCNJ8
Identifiers
Aliases	KCNJ8, KIR6.1, uKATP-1, potassium voltage-gated channel subfamily J member 8, potassium inwardly rectifying channel subfamily J member 8
External IDs	OMIM: 600935 MGI: 1100508 HomoloGene: 3654 GeneCards: KCNJ8
Gene location (Human)
Chr.	Chromosome 12 (human)
End	21,775,600 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	142,517,340 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; body of pancreas; ; right lobe of liver; ; gastric mucosa; ; pericardium; ; subcutaneous adipose tissue; ; visceral pleura; ; parietal pleura; ; popliteal artery; ; right lung;
	Top expressed in
	internal carotid artery; ; ascending aorta; ; molar; ; aortic valve; ; myocardium of ventricle; ; digastric muscle; ; cardiac muscles; ; external carotid artery; ; interventricular septum; ; soleus muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	voltage-gated ion channel activity; ATP binding; inward rectifier potassium channel activity; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization; ATP-activated inward rectifier potassium channel activity; sulfonylurea receptor binding;
Cellular component	integral component of membrane; membrane; intracellular membrane-bounded organelle; voltage-gated potassium channel complex; plasma membrane; myofibril; mitochondrion; inward rectifying potassium channel; sarcolemma;
Biological process	response to exogenous dsRNA; kidney development; regulation of ion transmembrane transport; ion transport; heart development; response to lipopolysaccharide; defense response to virus; potassium ion transport; membrane repolarization during ventricular cardiac muscle cell action potential; potassium ion import across plasma membrane; ion transmembrane transport; potassium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	3764
	16523
	ENSG00000121361
	ENSMUSG00000030247
	Q15842
	P97794
	NM_004982
	NM_008428; NM_001330363; NM_001330366
	NP_004973
	NP_001317292; NP_001317295; NP_032454
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium inwardly-rectifying channel, subfamily J, member 8, also known as KCNJ8, is a human gene encoding the K_ir6.1 protein. A mutation in KCNJ8 has been associated with cardiac arrest in the early repolarization syndrome.

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. K_ir6.1 is an integral membrane protein and inward-rectifier type potassium channel. K_ir6.1, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.