K_ir2.1

KCNJ2
Identifiers
Aliases	KCNJ2, ATFB9, HHBIRK1, HHIRK1, IRK1, KIR2.1, LQT7, SQT3, potassium voltage-gated channel subfamily J member 2, potassium inwardly rectifying channel subfamily J member 2
External IDs	OMIM: 600681 MGI: 104744 HomoloGene: 20249 GeneCards: KCNJ2
Gene location (Human)
Chr.	Chromosome 17 (human)
End	70,180,044 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	110,967,647 bp
RNA expression pattern
	Top expressed in
	inferior ganglion of vagus nerve; ; pons; ; subthalamic nucleus; ; corpus callosum; ; superior vestibular nucleus; ; inferior olivary nucleus; ; body of tongue; ; vastus lateralis muscle; ; deltoid muscle; ; ventral tegmental area;
	Top expressed in
	superior frontal gyrus; ; lip; ; temporal muscle; ; esophagus; ; upper arm; ; membranous bone; ; maxilla; ; human mandible; ; interventricular septum; ; skeletal muscle tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization; voltage-gated ion channel activity; identical protein binding; phosphatidylinositol-4,5-bisphosphate binding; inward rectifier potassium channel activity; G-protein activated inward rectifier potassium channel activity;
Cellular component	integral component of membrane; rough endoplasmic reticulum; Golgi apparatus; membrane; intercalated disc; T-tubule; voltage-gated potassium channel complex; plasma membrane; dendritic spine; integral component of plasma membrane; smooth endoplasmic reticulum; neuronal cell body; dendrite; intrinsic component of membrane;
Biological process	cardiac muscle cell action potential; regulation of ion transmembrane transport; magnesium ion transport; cardiac muscle cell action potential involved in contraction; ion transport; cellular potassium ion homeostasis; potassium ion transport; regulation of cardiac muscle cell contraction; cellular response to mechanical stimulus; membrane repolarization during action potential; potassium ion transmembrane transport; positive regulation of potassium ion transmembrane transport; regulation of skeletal muscle contraction via regulation of action potential; regulation of resting membrane potential; regulation of membrane repolarization; relaxation of skeletal muscle; regulation of heart rate by cardiac conduction; membrane repolarization during cardiac muscle cell action potential; protein homotetramerization; relaxation of cardiac muscle; membrane depolarization during cardiac muscle cell action potential; potassium ion import across plasma membrane; cardiac conduction;
	Sources:Amigo / QuickGO
Orthologs
	3759
	16518
	ENSG00000123700
	ENSMUSG00000041695
	P63252
	P35561
	NM_000891
	NM_008425
	NP_000882
	NP_032451
	Wikidata
View/Edit Human	View/Edit Mouse

The K_ir2.1 inward-rectifier potassium channel is a lipid-gated ion channel encoded by the KCNJ2 gene.

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Kir2.1

K_ir2.1