KATNB1

KATNB1
Identifiers
Aliases	KATNB1, KAT, LIS6, katanin regulatory subunit B1
External IDs	OMIM: 602703 MGI: 1921437 HomoloGene: 4302 GeneCards: KATNB1
Gene location (Human)
Chr.	Chromosome 16 (human)
End	57,757,244 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	95,829,777 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; right uterine tube; ; Brodmann area 23; ; oocyte; ; prefrontal cortex; ; Brodmann area 9; ; endothelial cell; ; Brodmann area 10; ; cingulate gyrus; ; secondary oocyte;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; yolk sac; ; visual cortex; ; superior frontal gyrus; ; internal carotid artery; ; external carotid artery; ; medullary collecting duct; ; olfactory bulb;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein heterodimerization activity; microtubule-severing ATPase activity; microtubule binding; dynein complex binding; protein binding;
Cellular component	cytoplasm; microtubule organizing center; growth cone; nucleus; axon; spindle pole; membrane; centrosome; midbody; microtubule; neuronal cell body; microtubule cytoskeleton; plasma membrane; cytoskeleton; katanin complex; cytosol; spindle;
Biological process	positive regulation of neuron projection development; cell cycle; negative regulation of microtubule depolymerization; cell division; protein targeting; microtubule severing; positive regulation of cell death; positive regulation of microtubule depolymerization; microtubule depolymerization; mitotic chromosome movement towards spindle pole;
	Sources:Amigo / QuickGO
Orthologs
	10300
	74187
	ENSG00000140854
	ENSMUSG00000031787
	Q9BVA0
	Q8BG40
	NM_005886
	NM_028805
	NP_005877
	NP_083081
	Wikidata
View/Edit Human	View/Edit Mouse

Katanin p80 WD40-containing subunit B1 is a protein that in humans is encoded by the KATNB1 gene.

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases. KATNB1 is associated with microlissencephaly.

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