KATNA1

KATNA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2RPA
Identifiers
Aliases	KATNA1, katanin catalytic subunit A1
External IDs	OMIM: 606696 MGI: 1344353 HomoloGene: 56014 GeneCards: KATNA1
Gene location (Human)
Chr.	Chromosome 6 (human)
End	149,648,972 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	7,638,914 bp
RNA expression pattern
	Top expressed in
	sperm; ; secondary oocyte; ; Achilles tendon; ; retinal pigment epithelium; ; gastrocnemius muscle; ; gastric mucosa; ; ascending aorta; ; monocyte; ; ganglionic eminence; ; left coronary artery;
	Top expressed in
	bone marrow; ; zone of skin; ; ileum; ; thymus; ; secondary oocyte; ; esophagus; ; duodenum; ; jejunum; ; proximal tubule; ; placenta;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; microtubule binding; microtubule-severing ATPase activity; protein binding; protein heterodimerization activity; hydrolase activity; ATP binding; ATPase activity; isomerase activity;
Cellular component	cytoplasm; spindle pole; midbody; microtubule; cytoskeleton; nucleus; microtubule organizing center; spindle; mitotic spindle pole; centrosome;
Biological process	cell division; microtubule severing; cell cycle; cytoplasmic microtubule organization;
	Sources:Amigo / QuickGO
Orthologs
	11104
	23924
	ENSG00000186625
	ENSMUSG00000019794
	O75449
	Q9WV86
	NM_001204076; NM_007044
	NM_011835
	NP_001191005; NP_008975
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Katanin p60 ATPase-containing subunit A1 is an enzyme that in humans is encoded by the KATNA1 gene.

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases.

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