John Isham
John Isham may refer to:
- Sir John Isham (1582–1651), High Sheriff of Northamptonshire
- John Isham (composer) (1680–1726), English composer and organist
- John Isham Farmstead, on the National Register of Historic Places listings in Lucas County, Ohio
- John William Isham (1866–?), American vaudeville impresario
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