JWH-250

JWH-250
Legal status
Legal status	AU: S9 (Prohibited substance); BR: Class F2 (Prohibited psychotropics); CA: Schedule II; DE: Anlage II (Authorized trade only, not prescriptible); UK: Class B; US: Schedule I; Illegal in Czech Republic and Latvia;
Identifiers
	IUPAC name 2-(2-Methoxyphenyl)-1-(1-pentylindol-3-yl)ethanone;
CAS Number	864445-43-2 ;
PubChem CID	44397540;
ChemSpider	23256117 ;
UNII	IP9911R8A0;
ChEMBL	ChEMBL188031 ;
CompTox Dashboard (EPA)	DTXSID40235556 ;
Chemical and physical data
Formula	C22H25NO2
Molar mass	335.447 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COc2ccccc2CC(=O)c(c3ccccc13)cn1CCCCC;
	InChI InChI=1S/C22H25NO2/c1-3-4-9-14-23-16-19(18-11-6-7-12-20(18)23)21(24)15-17-10-5-8-13-22(17)25-2/h5-8,10-13,16H,3-4,9,14-15H2,1-2H3 ; Key:FFLSJIQJQKDDCM-UHFFFAOYSA-N ;
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JWH-250 or (1-pentyl-3-(2-methoxyphenylacetyl)indole) is an analgesic chemical from the phenylacetylindole family that acts as a cannabinoid agonist at both the CB₁ and CB₂ receptors, with a K_i of 11 nM at CB₁ and 33 nM at CB₂. Unlike many of the older JWH series compounds, this compound does not have a naphthalene ring, instead occupying this position with a 2'-methoxy-phenylacetyl group, making JWH-250 a representative member of a new class of cannabinoid ligands. Other 2'-substituted analogues such as the methyl, chloro and bromo compounds are also active and somewhat more potent.

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