Janus kinase 3

JAK3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4RIO, 1YVJ, 3LXK, 3LXL, 3PJC, 3ZC6, 3ZEP, 4HVD, 4HVG, 4HVH, 4HVI, 4I6Q, 4QPS, 4QT1, 4V0G, 4Z16
Identifiers
Aliases	JAK3, JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK, Janus kinase 3
External IDs	OMIM: 600173 MGI: 99928 HomoloGene: 181 GeneCards: JAK3
Gene location (Human)
Chr.	Chromosome 19 (human)
End	17,848,071 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	72,143,219 bp
RNA expression pattern
	Top expressed in
	blood; ; spleen; ; lymph node; ; monocyte; ; appendix; ; superficial temporal artery; ; thymus; ; bone marrow cells; ; upper lobe of left lung; ; pancreatic ductal cell;
	Top expressed in
	thymus; ; lymph node; ; yolk sac; ; spleen; ; subcutaneous adipose tissue; ; lip; ; superior frontal gyrus; ; brown adipose tissue; ; temporal muscle; ; skeletal muscle tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; non-membrane spanning protein tyrosine kinase activity; kinase activity; protein binding; protein tyrosine kinase activity; protein phosphatase binding; signaling receptor binding; ATP binding;
Cellular component	cytoplasm; membrane; extrinsic component of cytoplasmic side of plasma membrane; cytoskeleton; endomembrane system; cytosol; endosome; plasma membrane;
Biological process	negative regulation of FasL production; negative regulation of interleukin-10 production; growth hormone receptor signaling pathway via JAK-STAT; response to interleukin-15; intracellular signal transduction; adaptive immune response; response to interleukin-4; phosphorylation; interleukin-4-mediated signaling pathway; immune system process; response to interleukin-2; negative regulation of thymocyte apoptotic process; MAPK cascade; T cell homeostasis; tyrosine phosphorylation of STAT protein; protein phosphorylation; negative regulation of T-helper 1 cell differentiation; negative regulation of dendritic cell cytokine production; regulation of T cell apoptotic process; positive regulation of T cell proliferation; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; B cell differentiation; negative regulation of T cell activation; enzyme linked receptor protein signaling pathway; cell migration; response to interleukin-9; negative regulation of interleukin-12 production; innate immune response; inflammatory response; erythrocyte differentiation; regulation of apoptotic process; interleukin-7-mediated signaling pathway; interleukin-15-mediated signaling pathway; interleukin-9-mediated signaling pathway; cytokine-mediated signaling pathway; interleukin-2-mediated signaling pathway; interleukin-21-mediated signaling pathway; regulation of receptor signaling pathway via JAK-STAT;
	Sources:Amigo / QuickGO
Orthologs
	3718
	16453
	ENSG00000105639
	ENSMUSG00000031805
	P52333
	Q62137
	NM_000215
	NM_001190830; NM_010589
	NP_000206
	NP_001177759; NP_034719
	Wikidata
View/Edit Human	View/Edit Mouse

Tyrosine-protein kinase JAK3 is a tyrosine kinase enzyme that in humans is encoded by the JAK3 gene.

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