Issaquena County, Mississippi

Issaquena County (/ˌɪsəˈkwnə/, ISS-ə-KWEEN-ə) is a county located in the U.S. state of Mississippi. As of the 2020 Census, its population was 1,338, making it the least populous county in the United States east of the Mississippi River. Its county seat is Mayersville. With a per-capita income of $18,598, Issaquena County is, by that measure, one of the poorest counties in the United States.

Issaquena County
Historic photo of the Issaquena County Courthouse in Mayersville, Mississippi
Location within the U.S. state of Mississippi
Mississippi's location within the U.S.
Coordinates: 32°44′N 90°59′W
Country United States
State Mississippi
FoundedJanuary 23, 1844
SeatMayersville
Largest townMayersville
Area
  Total441 sq mi (1,140 km2)
  Land413 sq mi (1,070 km2)
  Water28 sq mi (70 km2)  6.4%
Population
 (2020)
  Total1,338
  Estimate 
(2022)
1,273
  Density3.0/sq mi (1.2/km2)
Time zoneUTC−6 (Central)
  Summer (DST)UTC−5 (CDT)
Congressional district2nd

Issaquena County is located in the Mississippi Delta region. The Mississippi River flows along the entire western boundary of the county, and many of the earliest communities were river ports.

The county's economy is chiefly based on agriculture, though a number of hunting camps are also located here and contribute to the economy. Mississippi's two most recent records for the heaviest alligator taken by a hunter have both been in Issaquena County, the latest in 2012 when a 697.5 lb (316.4 kg) alligator was killed at a camp near Fitler.

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