Isocitrate lyase
Isocitrate lyase (EC 4.1.3.1), or ICL, is an enzyme in the glyoxylate cycle that catalyzes the cleavage of isocitrate to succinate and glyoxylate. Together with malate synthase, it bypasses the two decarboxylation steps of the tricarboxylic acid cycle (TCA cycle) and is used by bacteria, fungi, and plants.
| Isocitrate Lyase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Homotetrameric structure of Isocitrate lyase from E. coli. Based on PDB 1IGW. | |||||||||
| Identifiers | |||||||||
| EC no. | 4.1.3.1 | ||||||||
| CAS no. | 9045-78-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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| Isocitrate lyase family | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | ICL | ||||||||
| Pfam | PF00463 | ||||||||
| InterPro | IPR000918 | ||||||||
| PROSITE | PDOC00145 | ||||||||
| SCOP2 | 1f8m / SCOPe / SUPFAM | ||||||||
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The systematic name of this enzyme class is isocitrate glyoxylate-lyase (succinate-forming). Other names in common use include isocitrase, isocitritase, isocitratase, threo-Ds-isocitrate glyoxylate-lyase, and isocitrate glyoxylate-lyase. This enzyme participates in glyoxylate and dicarboxylate metabolism.
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