IDH2

IDH2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4JA8
Identifiers
Aliases	IDH2, D2HGA2, ICD-M, IDH, IDHM, IDP, IDPM, mNADP-IDH, isocitrate dehydrogenase (NADP(+)) 2, mitochondrial, isocitrate dehydrogenase (NADP(+)) 2, IDH-2
External IDs	OMIM: 147650 MGI: 96414 HomoloGene: 37590 GeneCards: IDH2
Gene location (Human)
Chr.	Chromosome 15 (human)
End	90,102,477 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	79,765,140 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; body of tongue; ; vastus lateralis muscle; ; triceps brachii muscle; ; left ventricle; ; skeletal muscle tissue; ; right ventricle; ; thoracic diaphragm; ; deltoid muscle; ; renal medulla;
	Top expressed in
	right ventricle; ; myocardium of ventricle; ; atrium; ; plantaris muscle; ; soleus muscle; ; atrioventricular valve; ; thoracic diaphragm; ; proximal tubule; ; otic placode; ; endocardial cushion;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; oxidoreductase activity; isocitrate dehydrogenase activity; NAD binding; magnesium ion binding; metal ion binding; isocitrate dehydrogenase (NADP+) activity; protein homodimerization activity;
Cellular component	mitochondrial inner membrane; cytosol; mitochondrial matrix; peroxisome; extracellular exosome; mitochondrion;
Biological process	2-oxoglutarate metabolic process; glyoxylate cycle; isocitrate metabolic process; tricarboxylic acid cycle; NADP biosynthetic process; negative regulation of glial cell proliferation; negative regulation of glial cell migration; negative regulation of matrix metallopeptidase secretion; mitochondrion organization; carbohydrate metabolic process; NADP metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	3418
	269951
	ENSG00000182054
	ENSMUSG00000030541
	P48735
	P54071
	NM_002168; NM_001289910; NM_001290114
	NM_173011
	NP_001276839; NP_001277043; NP_002159
	NP_766599
	Wikidata
View/Edit Human	View/Edit Mouse

Isocitrate dehydrogenase [NADP], mitochondrial is an enzyme that in humans is encoded by the IDH2 gene.

Isocitrate dehydrogenases are enzymes that catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by the IDH2 gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Somatic mosaic mutations of this gene have also been found associated to Ollier disease and Maffucci syndrome.

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