Iohexol

Iohexol
Clinical data
Trade names	Omnipaque, Hexopaque, Oraltag, others
Other names	5-[N-(2,3-Dihydroxypropyl)acetamido]-2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)isophthalamide
AHFS/Drugs.com	Micromedex Detailed Consumer Information
License data	US DailyMed: Iohexol;
Routes of; administration	Intrathecal, intravascular, by mouth, intracavital, rectal
ATC code	V08AB02 (WHO) ;
Legal status
Legal status	CA: ℞-only; US: WARNINGRx-only; In general: ℞ (Prescription only);
Pharmacokinetic data
Protein binding	Low
Metabolism	Nil
Elimination half-life	Variable
Excretion	Kidney, unchanged
Identifiers
	IUPAC name 1-N,3-N-Bis(2,3-dihydroxypropyl)-5-[N-(2,3-dihydroxypropyl)acetamido]-2,4,6-triiodobenzene-1,3-dicarboxamide;
CAS Number	66108-95-0 ;
PubChem CID	3730;
DrugBank	DB01362 ;
ChemSpider	3599 ;
UNII	4419T9MX03;
KEGG	D01817 ;
ChEBI	CHEBI:31709 ;
ChEMBL	ChEMBL1200455 ;
CompTox Dashboard (EPA)	DTXSID6023157 ;
ECHA InfoCard	100.060.130
Chemical and physical data
Formula	C19H26I3N3O9
Molar mass	821.142 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	174 to 180 °C (345 to 356 °F)
	SMILES O=C(N(c1c(I)c(c(I)c(c1I)C(=O)NCC(O)CO)C(=O)NCC(O)CO)CC(O)CO)C;
	InChI InChI=1S/C19H26I3N3O9/c1-8(29)25(4-11(32)7-28)17-15(21)12(18(33)23-2-9(30)5-26)14(20)13(16(17)22)19(34)24-3-10(31)6-27/h9-11,26-28,30-32H,2-7H2,1H3,(H,23,33)(H,24,34) ; Key:NTHXOOBQLCIOLC-UHFFFAOYSA-N ;
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Iohexol, sold under the trade name Omnipaque among others, is a contrast agent used for X-ray imaging. This includes when visualizing arteries, veins, ventricles of the brain, the urinary system, and joints, as well as during computed tomography (CT scan). It is given by mouth, injection into a vein, or into a body cavity.

Side effects include vomiting, skin flushing, headache, itchiness, kidney problems, and low blood pressure. Less commonly allergic reactions or seizures may occur. Allergies to povidone-iodine or shellfish do not affect the risk of side effects more than other allergies. Use in the later part of pregnancy may cause hypothyroidism in the baby. Iohexol is an iodinated non-ionic radiocontrast agent. It is in the low osmolar family.

Iohexol was approved for medical use in 1985. It is on the World Health Organization's List of Essential Medicines.

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