Interleukin 15

IL15
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2XQB, 2Z3Q, 2Z3R, 4GS7
Identifiers
Aliases	IL15, IL-15, interleukin 15
External IDs	OMIM: 600554 MGI: 103014 HomoloGene: 487 GeneCards: IL15
Gene location (Human)
Chr.	Chromosome 4 (human)
End	141,733,987 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	83,129,851 bp
RNA expression pattern
	Top expressed in
	monocyte; ; stromal cell of endometrium; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; spleen; ; gastric mucosa; ; ascending aorta; ; right coronary artery; ; jejunal mucosa; ; left coronary artery;
	Top expressed in
	right ventricle; ; cardiac muscles; ; myocardium of ventricle; ; duodenum; ; proximal tubule; ; seminal vesicula; ; jejunum; ; intercostal muscle; ; interventricular septum; ; colon;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; cytokine receptor binding; cytokine activity;
Cellular component	nucleus; integral component of plasma membrane; Golgi apparatus; endosome; nucleoplasm; membrane; cell surface; extracellular region; extracellular space; cytoplasm; cytosol; nuclear speck;
Biological process	negative regulation of smooth muscle cell proliferation; cell maturation; extrathymic T cell selection; positive regulation of T cell proliferation; regulation of defense response to virus by host; positive regulation of inflammatory response; response to nutrient levels; positive regulation of protein O-linked glycosylation; positive regulation of interleukin-17 production; hyaluronan metabolic process; positive regulation of natural killer cell differentiation; regulation of T cell differentiation; positive regulation of tissue remodeling; cellular response to vitamin D; lymph node development; natural killer cell differentiation; positive regulation of natural killer cell proliferation; cell-cell signaling; skeletal muscle atrophy; signal transduction; human ageing; NK T cell proliferation; positive regulation of immune response; inflammatory response; immune response; positive regulation of cell population proliferation; tyrosine phosphorylation of STAT protein; positive regulation of tyrosine phosphorylation of STAT protein; regulation of signaling receptor activity; interleukin-15-mediated signaling pathway; neutrophil activation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phagocytosis; negative regulation of cold-induced thermogenesis; macrophage differentiation;
	Sources:Amigo / QuickGO
Orthologs
	3600
	16168
	ENSG00000164136
	ENSMUSG00000031712
	P40933
	P48346
	NM_000585; NM_172174; NM_172175
	NM_001254747; NM_008357
	NP_000576; NP_751915
	NP_001241676; NP_032383
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin-15 (IL-15) is a protein that in humans is encoded by the IL15 gene. IL-15 is an inflammatory cytokine with structural similarity to Interleukin-2 (IL-2). Like IL-2, IL-15 binds to and signals through a complex composed of IL-2/IL-15 receptor beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces the proliferation of natural killer cells, i.e. cells of the innate immune system whose principal role is to kill virally infected cells.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.