Interleukin-9 receptor

IL9R
Identifiers
Aliases	IL9R, CD129, IL-9R, interleukin 9 receptor
External IDs	OMIM: 300007 MGI: 96564 HomoloGene: 37591 GeneCards: IL9R
Gene location (Human)
Chr.	X chromosome (human)
End	156,010,817 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	32,150,279 bp
RNA expression pattern
	Top expressed in
	lymph node; ; appendix; ; spleen; ; right uterine tube; ; rectum; ; urinary bladder; ; blood; ; gallbladder; ; thymus; ; upper lobe of left lung;
	Top expressed in
	spermatocyte; ; thymus; ; spermatid; ; spleen; ; embryo; ; lip; ; adrenal gland; ; muscle; ; heart; ; muscle tissue;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	cytokine receptor activity; interleukin-9 receptor activity; protein binding;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; extracellular region; extracellular space; plasma membrane;
Biological process	cell population proliferation; signal transduction; interleukin-9-mediated signaling pathway; regulation of cell population proliferation;
	Sources:Amigo / QuickGO
Orthologs
	3581
	16199
	ENSG00000124334
	ENSMUSG00000020279
	Q01113
	Q01114
	NM_002186; NM_176786
	NM_001134458; NM_008374
	NP_002177; NP_789743
	NP_001127930; NP_032400
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin 9 receptor (IL9R) also known as CD129 (Cluster of Differentiation 129) is a type I cytokine receptor. IL9R also denotes its human gene.

The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

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