Interleukin 7

IL7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3DI2, 3DI3
Identifiers
Aliases	IL7, IL-7, interleukin 7
External IDs	OMIM: 146660 MGI: 96561 HomoloGene: 680 GeneCards: IL7
Gene location (Human)
Chr.	Chromosome 8 (human)
End	78,805,523 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	7,678,820 bp
RNA expression pattern
	Top expressed in
	sperm; ; bronchial epithelial cell; ; Achilles tendon; ; jejunal mucosa; ; lower lobe of lung; ; caput epididymis; ; lymph node; ; right uterine tube; ; rectum; ; superficial temporal artery;
	Top expressed in
	secondary oocyte; ; thymus; ; left colon; ; Paneth cell; ; ileum; ; spleen; ; calvaria; ; pharynx; ; submandibular gland; ; facial motor nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; interleukin-7 receptor binding; growth factor activity; cytokine receptor binding; cytokine activity;
Cellular component	extracellular space; extracellular region; collagen-containing extracellular matrix;
Biological process	negative regulation of catalytic activity; cell-cell signaling; negative regulation of extrinsic apoptotic signaling pathway; positive regulation of organ growth; negative regulation of apoptotic process; bone resorption; humoral immune response; immune response; positive regulation of cell population proliferation; animal organ morphogenesis; regulation of gene expression; homeostasis of number of cells within a tissue; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; T cell lineage commitment; positive regulation of B cell proliferation; positive regulation of T cell differentiation; interleukin-7-mediated signaling pathway; regulation of signaling receptor activity; positive regulation of cytokine-mediated signaling pathway; cytokine-mediated signaling pathway; positive regulation of chemokine production; regulation of peptidyl-tyrosine phosphorylation; positive regulation of gene expression; positive regulation of B cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	3574
	16196
	ENSG00000104432
	ENSMUSG00000040329
	P13232
	P10168
	NM_000880; NM_001199886; NM_001199887; NM_001199888
	NM_008371; NM_001313888; NM_001313889; NM_001313890
	NP_000871; NP_001186815; NP_001186816; NP_001186817
	NP_001300817; NP_001300818; NP_001300819; NP_032397
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin 7 (IL-7) is a protein that in humans is encoded by the IL7 gene.

IL-7 is a hematopoietic growth factor secreted by stromal cells in the bone marrow and thymus. It is also produced by keratinocytes, dendritic cells, hepatocytes, neurons, and epithelial cells, but is not produced by normal lymphocytes. A study also demonstrated how the autocrine production of the IL-7 cytokine mediated by T-cell acute lymphoblastic leukemia (T-ALL) can be involved in the oncogenic development of T-ALL and offer novel insights into T-ALL spreading.

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