Interleukin-17A

IL17A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2VXS, 4HR9, 4HSA, 4QHU, 5HHV, 5HHX
Identifiers
Aliases	IL17A, CTLA8, IL-17, IL-17A, IL17, CTLA-8, interleukin 17A, ILA17, Interleukin 17A
External IDs	OMIM: 603149 MGI: 107364 HomoloGene: 1651 GeneCards: IL17A
Gene location (Human)
Chr.	Chromosome 6 (human)
End	52,190,638 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	20,804,720 bp
RNA expression pattern
	Top expressed in
	appendix; ; pylorus; ; palpebral conjunctiva; ; gallbladder; ; thymus; ; human penis; ; duodenum; ; urinary bladder; ; smooth muscle tissue; ; rectum;
	Top expressed in
	digastric muscle; ; right ventricle; ; submandibular gland; ; carotid body; ; ileum; ; jejunum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	cytokine activity; protein binding;
Cellular component	external side of plasma membrane; extracellular region; extracellular space;
Biological process	positive regulation of cytokine production involved in inflammatory response; cell-cell signaling; positive regulation of osteoclast differentiation; cell death; defense response to fungus; cellular response to interleukin-1; immune response; fibroblast activation; positive regulation of interleukin-23 production; positive regulation of transcription by RNA polymerase II; apoptotic process; inflammatory response; regulation of signaling receptor activity; cytokine-mediated signaling pathway; interleukin-17-mediated signaling pathway; granulocyte migration;
	Sources:Amigo / QuickGO
Orthologs
	3605
	16171
	ENSG00000112115
	ENSMUSG00000025929
	Q16552
	Q62386
	NM_002190
	NM_010552
	NP_002181
	NP_034682
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin-17A is a protein that in humans is encoded by the IL17A gene. In rodents, IL-17A used to be referred to as CTLA8, after the similarity with a viral gene (O40633).

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.