Glycoprotein IIb/IIIa
In biochemistry and medicine, glycoprotein IIb/IIIa (GPIIb/IIIa, also known as integrin αIIbβ3) is an integrin complex found on platelets. It is a transmembrane receptor for fibrinogen and von Willebrand factor, and aids platelet activation. The complex is formed via calcium-dependent association of gpIIb and gpIIIa, a required step in normal platelet aggregation and endothelial adherence. Platelet activation by ADP (blocked by clopidogrel) leads to the aforementioned conformational change in platelet gpIIb/IIIa receptors that induces binding to fibrinogen. The gpIIb/IIIa receptor is a target of several drugs including abciximab, eptifibatide, and tirofiban.
| integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | ITGA2B | ||||||
| Alt. symbols | GP2B | ||||||
| NCBI gene | 3674 | ||||||
| HGNC | 6138 | ||||||
| OMIM | 607759 | ||||||
| RefSeq | NM_000419 | ||||||
| UniProt | P08514 | ||||||
| Other data | |||||||
| Locus | Chr. 17 q21.32 | ||||||
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| integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | ITGB3 | ||||||
| Alt. symbols | GP3A | ||||||
| NCBI gene | 3690 | ||||||
| HGNC | 6156 | ||||||
| OMIM | 173470 | ||||||
| RefSeq | NM_000212 | ||||||
| UniProt | P05106 | ||||||
| Other data | |||||||
| Locus | Chr. 17 q21.32 | ||||||
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