Insulin-like growth factor 1 receptor

IGF1R
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IGR, 1JQH, 1K3A, 1M7N, 1P4O, 2OJ9, 2ZM3, 3D94, 3F5P, 3I81, 3LVP, 3LW0, 3NW5, 3NW6, 3NW7, 3O23, 3QQU, 4D2R, 4XSS, 5HZN
Identifiers
Aliases	IGF1R, CD221, IGFIR, IGFR, JTK13, insulin like growth factor 1 receptor, Insulin-like growth factor 1，IGF-1R
External IDs	OMIM: 147370 MGI: 96433 HomoloGene: 30997 GeneCards: IGF1R
Gene location (Human)
Chr.	Chromosome 15 (human)
End	98,964,530 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	67,883,416 bp
RNA expression pattern
	Top expressed in
	caput epididymis; ; corpus epididymis; ; renal medulla; ; saphenous vein; ; lactiferous duct; ; sural nerve; ; bronchial epithelial cell; ; retinal pigment epithelium; ; stromal cell of endometrium; ; seminal vesicula;
	Top expressed in
	molar; ; ciliary body; ; retinal pigment epithelium; ; conjunctival fornix; ; seminal vesicula; ; pineal gland; ; cumulus cell; ; ascending aorta; ; right lung lobe; ; maxillary prominence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; insulin-like growth factor binding; insulin receptor binding; insulin binding; kinase activity; phosphatidylinositol 3-kinase binding; insulin-like growth factor-activated receptor activity; protein binding; identical protein binding; transmembrane receptor protein tyrosine kinase activity; insulin receptor substrate binding; protein tyrosine kinase activity; ATP binding; insulin-like growth factor I binding; insulin-activated receptor activity;
Cellular component	integral component of membrane; membrane; intracellular membrane-bounded organelle; receptor complex; plasma membrane; integral component of plasma membrane; alphav-beta3 integrin-IGF-1-IGF1R complex; insulin receptor complex; axon;
Biological process	insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration; negative regulation of apoptotic process; protein tetramerization; positive regulation of DNA replication; protein phosphorylation; regulation of JNK cascade; immune response; positive regulation of cell population proliferation; peptidyl-tyrosine autophosphorylation; protein autophosphorylation; phosphatidylinositol 3-kinase signaling; phosphatidylinositol-mediated signaling; signal transduction; positive regulation of phosphatidylinositol 3-kinase signaling; glucose homeostasis; positive regulation of protein-containing complex disassembly; positive regulation of MAPK cascade; anatomical structure development; positive regulation of protein kinase B signaling; cellular response to glucose stimulus; dendritic spine maintenance; amyloid-beta clearance; positive regulation of cold-induced thermogenesis; cellular response to amyloid-beta;
	Sources:Amigo / QuickGO
Orthologs
	3480
	16001
	ENSG00000140443
	ENSMUSG00000005533
	P08069
	Q60751
	NM_000875; NM_001291858; NM_152452
	NM_010513
	NP_000866; NP_001278787
	NP_034643
	Wikidata
View/Edit Human	View/Edit Mouse

The insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called insulin-like growth factor 1 (IGF-1) and by a related hormone called IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin. IGF-1 plays an important role in growth and continues to have anabolic effects in adults – meaning that it can induce hypertrophy of skeletal muscle and other target tissues. Mice lacking the IGF-1 receptor die late in development, and show a dramatic reduction in body mass. This testifies to the strong growth-promoting effect of this receptor.

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