Indoxyl sulfate

Indoxyl sulfate
Names
	Preferred IUPAC name 1H-Indol-3-yl hydrogen sulfate
	Other names 3-Indoxylsulfate; 3-Indoxylsulfuric acid; Indol-3-yl sulfate
Identifiers
CAS Number	487-94-5 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:43355;
ChEMBL	ChEMBL1233636;
ChemSpider	9840;
DrugBank	DB07992;
PubChem CID	10258;
UNII	KT0QA88913;
CompTox Dashboard (EPA)	DTXSID30928203 ;
	InChI InChI=1S/C8H7NO4S/c10-14(11,12)13-8-5-9-7-4-2-1-3-6(7)8/h1-5,9H,(H,10,11,12) Key: BXFFHSIDQOFMLE-UHFFFAOYSA-N;
	SMILES C1=CC=C2C(=C1)C(=CN2)OS(=O)(=O)O;
Properties
Chemical formula	C8H7NO4S
Molar mass	213.21 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Indoxyl sulfate, also known as 3-indoxylsulfate and 3-indoxylsulfuric acid, is a metabolite of dietary L-tryptophan that acts as a cardiotoxin and uremic toxin. High concentrations of indoxyl sulfate in blood plasma are known to be associated with the development and progression of chronic kidney disease and vascular disease in humans. As a uremic toxin, it stimulates glomerular sclerosis and renal interstitial fibrosis.

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