Indoprofen

Indoprofen
Clinical data
Routes of; administration	Oral
ATC code	M01AE10 (WHO) ;
Legal status
Legal status	Withdrawn;
Pharmacokinetic data
Bioavailability	High (rapid and complete absorption)
Metabolism	Glucuronidation
Elimination half-life	2.3 hours
Excretion	Renal
Identifiers
	IUPAC name 2-[4-(1-oxo-1,3-dihydro-2H-isoindol-2-yl); phenyl]propanoic acid;
CAS Number	31842-01-0 ;
PubChem CID	3718;
DrugBank	DB08951 ;
ChemSpider	3587 ;
UNII	CPE46ZU14N;
KEGG	D04530 ;
ChEBI	CHEBI:76162 ;
ChEMBL	ChEMBL15870 ;
CompTox Dashboard (EPA)	DTXSID5045831 ;
ECHA InfoCard	100.046.197
Chemical and physical data
Formula	C17H15NO3
Molar mass	281.311 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(O)C(c1ccc(cc1)N3C(=O)c2ccccc2C3)C;
	InChI InChI=1S/C17H15NO3/c1-11(17(20)21)12-6-8-14(9-7-12)18-10-13-4-2-3-5-15(13)16(18)19/h2-9,11H,10H2,1H3,(H,20,21) ; Key:RJMIEHBSYVWVIN-UHFFFAOYSA-N ;
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Indoprofen is a nonsteroidal anti-inflammatory drug (NSAID). It was withdrawn worldwide in the 1980s after postmarketing reports of severe gastrointestinal bleeding.

A 2004 study using high-throughput screening found indoprofen to increase production of the survival of motor neuron protein, suggesting it may provide insight into treatments for spinal muscular atrophies.

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