IRF4

IRF4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DLL
Identifiers
Aliases	IRF4, LSIRF, MUM1, NF-EM5, SHEP8, interferon regulatory factor 4
External IDs	OMIM: 601900 MGI: 1096873 HomoloGene: 1842 GeneCards: IRF4
Gene location (Human)
Chr.	Chromosome 6 (human)
End	411,443 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	30,950,959 bp
RNA expression pattern
	Top expressed in
	lymph node; ; canal of the cervix; ; appendix; ; bone marrow cells; ; spleen; ; rectum; ; superficial temporal artery; ; thymus; ; monocyte; ; duodenum;
	Top expressed in
	spleen; ; blood; ; subcutaneous adipose tissue; ; brown adipose tissue; ; mammary gland; ; submandibular gland; ; bone marrow; ; thymus; ; Paneth cell; ; white adipose tissue;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription factor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein-lysine N-methyltransferase activity; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytosol; membrane; nucleoplasm; nucleus;
Biological process	regulation of transcription, DNA-templated; interferon-gamma-mediated signaling pathway; regulation of T-helper cell differentiation; myeloid dendritic cell differentiation; transcription, DNA-templated; T-helper 17 cell lineage commitment; positive regulation of transcription, DNA-templated; peptidyl-lysine methylation; negative regulation of toll-like receptor signaling pathway; type I interferon signaling pathway; histone H3 acetylation; histone H4 acetylation; positive regulation of DNA binding; T cell activation; positive regulation of transcription by RNA polymerase II; defense response to protozoan; protein methylation; transcription by RNA polymerase II; cytokine-mediated signaling pathway; positive regulation of cold-induced thermogenesis; immune system process;
	Sources:Amigo / QuickGO
Orthologs
	3662
	16364
	ENSG00000137265
	ENSMUSG00000021356
	Q15306
	Q64287
	NM_001195286; NM_002460
	NM_013674; NM_001347508
	NP_001182215; NP_002451
	NP_001334437; NP_038702
	Wikidata
View/Edit Human	View/Edit Mouse

Interferon regulatory factor 4 (IRF4) also known as MUM1 is a protein that in humans is encoded by the IRF4 gene. IRF4 functions as a key regulatory transcription factor in the development of human immune cells. The expression of IRF4 is essential for the differentiation of T lymphocytes and B lymphocytes as well as certain myeloid cells. Dysregulation of the IRF4 gene can result in IRF4 functioning either as an oncogene or a tumor-suppressor, depending on the context of the modification.

The MUM1 symbol is also the current HGNC official symbol for melanoma associated antigen (mutated) 1 (HGNC:29641).

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