IRAK1

IRAK1
Identifiers
Aliases	IRAK1, IRAK, pelle, interleukin 1 receptor associated kinase 1
External IDs	OMIM: 300283 MGI: 107420 HomoloGene: 37496 GeneCards: IRAK1
Gene location (Human)
Chr.	X chromosome (human)
End	154,019,902 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	73,067,524 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; pancreatic ductal cell; ; endothelial cell; ; periodontal fiber; ; duodenum; ; epithelium of esophagus; ; stromal cell of endometrium; ; kidney tubule; ; superior surface of tongue; ; appendix;
	Top expressed in
	lacrimal gland; ; parotid gland; ; submandibular gland; ; Paneth cell; ; islet of Langerhans; ; seminal vesicula; ; body of femur; ; substantia nigra; ; cervix; ; ciliary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; heat shock protein binding; protein homodimerization activity; kinase activity; NF-kappaB-inducing kinase activity; protein binding; protein heterodimerization activity; ATP binding; protein serine/threonine kinase activity;
Cellular component	membrane; lipid droplet; plasma membrane; endosome membrane; interleukin-1 receptor complex; nucleus; cytoplasm; cytosol;
Biological process	cellular response to heat; response to interleukin-1; positive regulation of MAP kinase activity; regulation of cytokine-mediated signaling pathway; phosphorylation; cytokine-mediated signaling pathway; immune system process; human ageing; negative regulation of apoptotic process; activation of NF-kappaB-inducing kinase activity; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; positive regulation of transcription, DNA-templated; protein phosphorylation; JNK cascade; response to lipopolysaccharide; transmembrane receptor protein serine/threonine kinase signaling pathway; positive regulation of NF-kappaB transcription factor activity; protein complex oligomerization; positive regulation of I-kappaB kinase/NF-kappaB signaling; protein autophosphorylation; toll-like receptor 9 signaling pathway; cellular response to lipopolysaccharide; negative regulation of NF-kappaB transcription factor activity; nucleotide-binding oligomerization domain containing signaling pathway; positive regulation of type I interferon production; cellular response to hypoxia; lipopolysaccharide-mediated signaling pathway; signal transduction; positive regulation of smooth muscle cell proliferation; toll-like receptor 4 signaling pathway; toll-like receptor 2 signaling pathway; innate immune response; type I interferon signaling pathway; viral process; interleukin-1-mediated signaling pathway; intracellular signal transduction; positive regulation of NIK/NF-kappaB signaling; positive regulation of leukocyte adhesion to vascular endothelial cell;
	Sources:Amigo / QuickGO
Orthologs
	3654
	16179
	ENSG00000184216
	ENSMUSG00000031392
	P51617
	Q62406
	NM_001025242; NM_001025243; NM_001569
	NM_001177973; NM_001177974; NM_001177975; NM_001177976; NM_008363
	NP_001020413; NP_001020414; NP_001560
	NP_001171444; NP_001171445; NP_001171446; NP_001171447; NP_032389
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin-1 receptor-associated kinase 1 (IRAK-1) is an enzyme in humans encoded by the IRAK1 gene. IRAK-1 plays an important role in the regulation of the expression of inflammatory genes by immune cells, such as monocytes and macrophages, which in turn help the immune system in eliminating bacteria, viruses, and other pathogens. IRAK-1 is part of the IRAK family consisting of IRAK-1, IRAK-2, IRAK-3, and IRAK-4, and is activated by inflammatory molecules released by signaling pathways during pathogenic attack. IRAK-1 is classified as a kinase enzyme, which regulates pathways in both innate and adaptive immune systems.

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