IL17RA

IL17RA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3JVF, 4HSA, 4NUX
Identifiers
Aliases	IL17RA, CANDF5, CD217, CDw217, IL-17RA, IL17R, hIL-17R, interleukin 17 receptor A, IMD51
External IDs	OMIM: 605461 MGI: 107399 HomoloGene: 7378 GeneCards: IL17RA
Gene location (Human)
Chr.	Chromosome 22 (human)
End	17,115,693 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	120,464,520 bp
RNA expression pattern
	Top expressed in
	blood; ; monocyte; ; spongy bone; ; bone marrow; ; bone marrow cells; ; internal globus pallidus; ; secondary oocyte; ; thymus; ; pancreatic ductal cell; ; inferior ganglion of vagus nerve;
	Top expressed in
	blood; ; thymus; ; aortic valve; ; ascending aorta; ; spleen; ; saccule; ; secondary oocyte; ; proximal tubule; ; subcutaneous adipose tissue; ; otic placode;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	interleukin-17 receptor activity; signaling receptor binding; protein binding;
Cellular component	integral component of membrane; extracellular region; integral component of plasma membrane; membrane; plasma membrane;
Biological process	positive regulation of cytokine production involved in inflammatory response; cell surface receptor signaling pathway; fibroblast activation; positive regulation of inflammatory response; granulocyte chemotaxis; positive regulation of interleukin-23 production; defense response to fungus; cellular response to cytokine stimulus; interleukin-17-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	23765
	16172
	ENSG00000177663
	ENSMUSG00000002897
	Q96F46
	Q60943
	NM_014339; NM_001289905
	NM_008359
	NP_001276834; NP_055154
	NP_032385
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin 17 receptor A, also known as IL17RA and CDw217 (cluster of differentiation w217), is a human gene.

Interleukin 17A (IL17A)is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure.

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