Interleukin 29

IFNL1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	3OG6, 3OG4
Identifiers
Aliases	IFNL1, IL-29, IL29, interferon, lambda 1, interferon lambda 1
External IDs	OMIM: 607403 HomoloGene: 131189 GeneCards: IFNL1
Gene location (Human)
Chr.	Chromosome 19 (human)
End	39,298,673 bp
RNA expression pattern
	Top expressed in
	blood; ; spleen; ; duodenum; ; cecum; ; appendix; ; respiratory system; ; gallbladder; ; lymph node; ; lower respiratory tract; ; lung;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity; interleukin-28 receptor binding; signaling receptor binding;
Cellular component	interleukin-28 receptor complex; intracellular anatomical structure; extracellular region; extracellular space;
Biological process	receptor signaling pathway via JAK-STAT; negative regulation of interleukin-5 production; positive regulation of tyrosine phosphorylation of STAT protein; positive regulation of interferon-gamma production; negative regulation of interleukin-13 production; positive regulation of transcription, DNA-templated; positive regulation of immune response; defense response to virus; negative regulation of type 2 immune response; innate immune response; negative regulation of transcription, DNA-templated; positive regulation of MHC class I biosynthetic process; negative regulation of memory T cell differentiation; negative regulation of T cell differentiation; positive regulation of receptor signaling pathway via JAK-STAT; negative regulation of cell population proliferation; regulation of signaling receptor activity; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	282618
	n/a
	ENSG00000182393
	n/a
	Q8IU54
	n/a
	NM_172140
	n/a
	NP_742152
	n/a
	Wikidata
View/Edit Human

Interleukin-29 (IL-29) is a cytokine and it belongs to type III interferons group, also termed interferons λ (IFN-λ). IL-29 (alternative name IFNλ1) plays an important role in the immune response against pathogenes and especially against viruses by mechanisms similar to type I interferons, but targeting primarily cells of epithelial origin and hepatocytes.

IL-29 is encoded by the IFNL1 gene located on chromosome 19 in humans. It is a pseudogene in mice meaning the IL-29 protein is not produced in them.

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