IκBα

NFKBIA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IKN, 1NFI
Identifiers
Aliases	NFKBIA, IKBA, MAD-3, NFKBI, NFKB inhibitor alpha, EDAID2
External IDs	OMIM: 164008 MGI: 104741 HomoloGene: 7863 GeneCards: NFKBIA
Gene location (Human)
Chr.	Chromosome 14 (human)
End	35,404,749 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	55,539,432 bp
RNA expression pattern
	Top expressed in
	vena cava; ; pericardium; ; lower lobe of lung; ; oocyte; ; nipple; ; saphenous vein; ; mucosa of urinary bladder; ; monocyte; ; upper lobe of lung; ; right lung;
	Top expressed in
	carotid body; ; Paneth cell; ; ciliary body; ; right lung lobe; ; left lung lobe; ; iris; ; cumulus cell; ; lacrimal gland; ; cervix; ; seminal vesicula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transcription factor binding; protein binding; nuclear localization sequence binding; identical protein binding; enzyme binding; ubiquitin protein ligase binding; heat shock protein binding; protein-containing complex binding; NF-kappaB binding;
Cellular component	cytoplasm; I-kappaB/NF-kappaB complex; plasma membrane; nucleus; cytosol; intracellular anatomical structure; protein-containing complex; nucleoplasm;
Biological process	response to muscle stretch; positive regulation of protein metabolic process; response to exogenous dsRNA; cytoplasmic sequestering of transcription factor; negative regulation of DNA binding; cellular response to organic cyclic compound; cytoplasmic sequestering of NF-kappaB; response to muramyl dipeptide; negative regulation of apoptotic process; cellular response to cytokine stimulus; positive regulation of transcription, DNA-templated; response to lipopolysaccharide; cellular response to cold; regulation of cell population proliferation; positive regulation of cholesterol efflux; nucleotide-binding oligomerization domain containing 2 signaling pathway; regulation of gene expression; negative regulation of lipid storage; viral process; negative regulation of NF-kappaB transcription factor activity; negative regulation of myeloid cell differentiation; negative regulation of macrophage derived foam cell differentiation; nucleotide-binding oligomerization domain containing 1 signaling pathway; lipopolysaccharide-mediated signaling pathway; negative regulation of Notch signaling pathway; positive regulation of transcription by RNA polymerase II; apoptotic process; liver regeneration; toll-like receptor 4 signaling pathway; protein deubiquitination; I-kappaB kinase/NF-kappaB signaling; tumor necrosis factor-mediated signaling pathway; positive regulation of inflammatory response; cellular response to tumor necrosis factor; interleukin-1-mediated signaling pathway; regulation of NIK/NF-kappaB signaling; protein import into nucleus;
	Sources:Amigo / QuickGO
Orthologs
	4792
	18035
	ENSG00000100906
	ENSMUSG00000021025
	P25963
	Q9Z1E3
	NM_020529
	NM_010907
	NP_065390
	NP_035037
	Wikidata
View/Edit Human	View/Edit Mouse

IκBα (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha; NFKBIA) is one member of a family of cellular proteins that function to inhibit the NF-κB transcription factor. IκBα inhibits NF-κB by masking the nuclear localization signals (NLS) of NF-κB proteins and keeping them sequestered in an inactive state in the cytoplasm. In addition, IκBα blocks the ability of NF-κB transcription factors to bind to DNA, which is required for NF-κB's proper functioning.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.