Hsp90 inhibitor
An Hsp90 inhibitor is a substance that inhibits that activity of the Hsp90 heat shock protein. Since Hsp90 stabilizes a variety of proteins required for survival of cancer cells, these substances may have therapeutic benefit in the treatment of various types of malignancies. Furthermore, a number of Hsp90 inhibitors are currently undergoing clinical trials for a variety of cancers. Hsp90 inhibitors include the natural products geldanamycin and radicicol as well as semisynthetic derivatives 17-N-Allylamino-17-demethoxygeldanamycin (17AAG).
| Hsp90 inhibitor | |
|---|---|
| Drug class | |
Geldanamycin, the first discovered Hsp90 inhibitor. | |
| Class identifiers | |
| Use | Antineoplastic |
| Biological target | Hsp90 |
| Legal status | |
| In Wikidata | |
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