Howell–Jolly body

A Howell–Jolly body is a cytopathological finding of basophilic nuclear remnants (clusters of DNA) in circulating erythrocytes. During maturation in the bone marrow, late erythroblasts normally expel their nuclei; but, in some cases, a small portion of DNA remains. The presence of Howell–Jolly bodies usually signifies a damaged or absent spleen, because a healthy spleen would normally filter such erythrocytes.

See also: Howell-Jolly body-like inclusions

The Howell–Jolly body is named after William Henry Howell and Justin Marie Jolly.

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