Highway 5 (Israel–Palestine)

Highway 5 or the Trans-Samaria Highway (Hebrew: כביש חוצה שומרון, Kvish Hotze Shomron), is one of Israel's main highways, connecting the Mediterranean coast immediately north of Tel Aviv with the central Sharon plain and eastwards to Ariel and other Israeli settlements in the northern West Bank.

The name Highway 5 is commonly used to describe the section of the highway running from the road's western end at the Glilot Interchange until it reaches the main entrance of Ariel. In this capacity it intersects and creates a connection between four important arterial freeways in the northern Tel Aviv area: The Coastal Highway (Highway 2), the Ayalon Highway (Highway 20), Geha Highway (Highway 4) and the Cross-Israel Highway (Highway 6).

An alternate name for the entire highway is Kvish Hotze Shomron meaning the Trans-Samaria Highway though often this name is used when referring specifically to the section of the road in the West Bank, i.e., past the Green Line, where it continues east towards the Jordan Valley in the West Bank. This section from the Green Line to its eastern end has also been dedicated as "Derekh Haim" (Haim's Road, but also "Way of Life") after the late Haim Landau, a former Israeli Minister of Transportation.