Hexamethonium

Hexamethonium
Clinical data
Pregnancy; category	D;
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	IUPAC name N,N,N,N',N',N-hexamethylhexane-1,6-diaminium;
CAS Number	60-26-4 ;
PubChem CID	3604;
IUPHAR/BPS	3963;
DrugBank	DB08960 ;
ChemSpider	3478 ;
UNII	3C9PSP36Z2;
ChEMBL	ChEMBL105608 ;
CompTox Dashboard (EPA)	DTXSID9045053 ;
Chemical and physical data
Formula	C12H30N2
Molar mass	202.386 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C(CCCC[N+](C)(C)C)C[N+](C)(C)C;
	InChI InChI=1S/C12H30N2/c1-13(2,3)11-9-7-8-10-12-14(4,5)6/h7-12H2,1-6H3/q+2 ; Key:VZJFGSRCJCXDSG-UHFFFAOYSA-N ;
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Hexamethonium is a non-depolarising ganglionic blocker, a neuronal nicotinic (nAChR) receptor antagonist that acts in autonomic ganglia by binding mostly in or on the nAChR receptor, and not the acetylcholine binding site itself. It does not have any effect on the muscarinic acetylcholine receptors (mAChR) located on target organs of the parasympathetic nervous system, nor on the nicotinic receptors at the skeletal neuromuscular junction, but acts as antagonist at the nicotinic acetylcholine receptors located in sympathetic and parasympathetic ganglia (nAChR).

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