Hepcidin

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Hepcidin
Hepcidin
	Solution structure of hepcidin-25.
Identifiers
Symbol	Hepcidin
Pfam	PF06446
InterPro	IPR010500
SCOP2	1m4f / SCOPe / SUPFAM
OPM superfamily	153
OPM protein	1m4e
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

HAMP
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1M4E, 1M4F, 2KEF, 3H0T, 4QAE
Identifiers
Aliases	HAMP, HEPC, HFE2B, LEAP1, PLTR, hepcidin antimicrobial peptide
External IDs	OMIM: 606464 HomoloGene: 81623 GeneCards: HAMP
Gene location (Human)
Chr.	Chromosome 19 (human)
End	35,285,143 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; optic nerve; ; caput epididymis; ; body of pancreas; ; pancreatic ductal cell; ; internal globus pallidus; ; substantia nigra; ; hypothalamus; ; vena cava; ; amygdala;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hormone activity; iron ion transmembrane transporter inhibitor activity; signaling receptor binding;
Cellular component	cytoplasm; extracellular region; apical cortex; intercalated disc; extracellular space;
Biological process	negative regulation of iron export across plasma membrane; negative regulation of intestinal absorption; positive regulation of receptor internalization; negative regulation of transcription by RNA polymerase II; negative regulation of iron ion transmembrane transporter activity; response to iron ion; multicellular organismal iron ion homeostasis; defense response to bacterium; immune response; positive regulation of receptor catabolic process; positive regulation of protein polyubiquitination; negative regulation of ion transmembrane transporter activity; cellular iron ion homeostasis; cellular response to lipopolysaccharide; human ageing; cellular response to tumor necrosis factor; liver regeneration; cellular response to bile acid; cellular response to interleukin-6; response to iron ion starvation; response to vitamin A; response to erythropoietin; positive regulation of cell growth involved in cardiac muscle cell development; response to ethanol; acute-phase response; cellular response to X-ray; response to zinc ion; negative regulation of iron ion transmembrane transport; antimicrobial humoral immune response mediated by antimicrobial peptide; killing of cells of other organism; defense response to fungus; regulation of signaling receptor activity; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	57817
	n/a
	ENSG00000105697
	n/a
	P81172
	n/a
	NM_021175
	n/a
	NP_066998
	n/a
	Wikidata
View/Edit Human

Hepcidin is a protein that in humans is encoded by the HAMP gene. Hepcidin is a key regulator of the entry of iron into the circulation in mammals.

hepcidin antimicrobial peptide

Identifiers

Symbol

NCBI gene

OMIM

RefSeq

UniProt

Other data

Locus

Chr. 19 q13.1

Search for
Structures	Swiss-model
Domains	InterPro

During conditions in which the hepcidin level is abnormally high, such as inflammation, serum iron falls due to iron trapping within macrophages and liver cells and decreased gut iron absorption. This typically leads to anemia due to an inadequate amount of serum iron being available for developing red blood cells. When the hepcidin level is abnormally low such as in hemochromatosis, iron overload occurs due to increased ferroportin mediated iron efflux from storage and increased gut iron absorption.

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