HSF1

HSF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LDU, 5D5U, 5D5V
Identifiers
Aliases	HSF1, HSTF1, heat shock transcription factor 1
External IDs	OMIM: 140580 MGI: 96238 HomoloGene: 74556 GeneCards: HSF1
Gene location (Human)
Chr.	Chromosome 8 (human)
End	144,314,720 bp
RNA expression pattern
	Top expressed in
	left ventricle; ; stromal cell of endometrium; ; gastrocnemius muscle; ; popliteal artery; ; fundus; ; body of stomach; ; skeletal muscle tissue; ; right coronary artery; ; prostate; ; body of pancreas;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; chromatin binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding; sequence-specific single stranded DNA binding; DNA binding; protein kinase binding; heat shock protein binding; chromatin DNA binding; identical protein binding; sequence-specific DNA binding; protein self-association; protein heterodimerization activity; Hsp90 protein binding; translation elongation factor binding; promoter-specific chromatin binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; STAT family protein binding;
Cellular component	cytoplasm; pronucleus; euchromatin; heterochromatin; nucleus; centrosome; cytosol; PML body; nuclear stress granule; mitotic spindle pole; ribonucleoprotein complex; chromosome, centromeric region; kinetochore; spindle pole; nucleoplasm; chromosome; microtubule organizing center; cytoskeleton; perinuclear region of cytoplasm; protein-containing complex;
Biological process	defense response; regulation of transcription, DNA-templated; embryonic placenta development; mRNA transcription; in utero embryonic development; negative regulation of transcription by RNA polymerase II; response to heat; female meiotic nuclear division; transcription, DNA-templated; embryonic process involved in female pregnancy; protein phosphorylation; response to lipopolysaccharide; spermatogenesis; positive regulation of multicellular organism growth; negative regulation of tumor necrosis factor production; positive regulation of transcription by RNA polymerase II; negative regulation of cell population proliferation; response to organonitrogen compound; cellular response to lipopolysaccharide; negative regulation of gene expression; cellular response to amino acid stimulus; cellular response to hydrogen peroxide; positive regulation of microtubule binding; response to peptide; cellular response to nitroglycerin; negative regulation of cardiac muscle cell apoptotic process; response to estradiol; cellular response to organic cyclic compound; positive regulation of gene expression; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; cellular response to potassium ion; response to amino acid; negative regulation of inclusion body assembly; positive regulation of apoptotic DNA fragmentation; cellular response to L-glutamine; response to psychosocial stress; response to organic cyclic compound; negative regulation of neuron death; response to nutrient; cellular response to angiotensin; response to testosterone; response to hypobaric hypoxia; response to activity; cellular response to radiation; cellular response to estradiol stimulus; positive regulation of inclusion body assembly; MAPK cascade; positive regulation of cell population proliferation; cellular response to heat; Unfolded Protein Response; regulation of protein heterodimerization activity; positive regulation of mitotic cell cycle; protein homooligomerization; positive regulation of transcription from RNA polymerase II promoter in response to heat stress; protein homotrimerization; cellular response to cadmium ion; cellular response to copper ion; cellular response to gamma radiation; cellular response to diamide; regulation of cellular response to heat; positive regulation of mRNA polyadenylation; cellular response to sodium arsenite; negative regulation of double-strand break repair via nonhomologous end joining; DNA repair; mRNA processing; cellular response to DNA damage stimulus; mRNA transport; positive regulation of tyrosine phosphorylation of STAT protein; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	3297
	15499
	ENSG00000185122; ENSG00000284774
	ENSMUSG00000022556
	Q00613
	P38532
	NM_005526
	NM_008296
	NP_005517
	NP_001318081; NP_001318082; NP_001318083; NP_001318143; NP_032322
	Wikidata
View/Edit Human	View/Edit Mouse

Heat shock factor 1 (HSF 1) is a protein that in humans is encoded by the HSF1 gene. HSF1 is highly conserved in eukaryotes and is the primary mediator of transcriptional responses to proteotoxic stress with important roles in non-stress regulation such as development and metabolism.

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