HMGN3

HMGN3
Identifiers
Aliases	HMGN3, PNAS-25, TRIP7, PNAS-24, high mobility group nucleosomal binding domain 3
External IDs	OMIM: 604502 HomoloGene: 130417 GeneCards: HMGN3
Gene location (Human)
Chr.	Chromosome 6 (human)
End	79,234,738 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; endothelial cell; ; palpebral conjunctiva; ; right uterine tube; ; parietal pleura; ; visceral pleura; ; hair follicle; ; germinal epithelium; ; glomerulus; ; metanephric glomerulus;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleosomal DNA binding; DNA binding; chromatin binding; thyroid hormone receptor binding;
Cellular component	chromatin; nucleus; nucleoplasm; cytosol;
Biological process	regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of transcription by RNA polymerase II; biological process; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	9324
	n/a
	ENSG00000118418
	n/a
	Q15651
	n/a
NM_001201362; NM_001201363; NM_004242; NM_138730; NM_001318884;
	NM_001318885; NM_001318886; NM_001318887; NM_001318888
	n/a
NP_001188291; NP_001188292; NP_001305813; NP_001305814; NP_001305815;
	NP_001305816; NP_001305817; NP_004233; NP_620058
	n/a
	Wikidata
View/Edit Human

High mobility group nucleosome-binding domain-containing protein 3 is a protein that in humans is encoded by the HMGN3 gene.

Thyroid hormone receptors are hormone-dependent transcription factors that regulate expression of a variety of specific target genes. The protein encoded by this gene binds thyroid hormone receptor beta, but only in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Two transcript variants encoding different isoforms have been found for this gene.

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