HLA-DRB1

HLA-DRB1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1A6A, 1BX2, 1YMM, 2WBJ,%%s1AQD, 1DLH, 1FYT, 1HXY, 1JWM, 1JWS, 1JWU, 1KG0, 1KLG, 1KLU, 1LO5, 1PYW, 1R5I, 1SEB, 1SJH, 1T5W, 1T5X, 2FSE, 2G9H, 2IAM, 2IAN, 2ICW, 2IPK, 2OJE, 2XN9, 3L6F, 3PDO, 3PGC, 3PGD, 3QXA, 3QXD, 3S4S, 3S5L, 4AEN, 4AH2, 4C56, 4E41, 4FQX, 4GBX, 4I5B, 4OV5, 4X5W, 4X5X,%%s1D5M, 1D5X, 1D5Z, 1D6E, 1J8H, 2SEB, 3O6F, 3T0E, 4IS6, 4MCY, 4MCZ, 4MD0, 4MD4, 4MD5, 4MDI, 4MDJ, 4Y19, 4Y1A
Identifiers
Aliases	HLA-DRB1, DRB1, DRw10, HLA-DR1B, HLA-DRB, SS1, major histocompatibility complex, class II, DR beta 1
External IDs	OMIM: 142857 HomoloGene: 136635 GeneCards: HLA-DRB1
Gene location (Human)
Chr.	Chromosome 6 (human)
End	32,589,848 bp
RNA expression pattern
	Top expressed in
	appendix; ; right lung; ; lymph node; ; spleen; ; upper lobe of left lung; ; monocyte; ; gallbladder; ; duodenum; ; right coronary artery; ; subcutaneous adipose tissue;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	peptide antigen binding; MHC class II receptor activity; protein binding; MHC class II protein complex binding;
Cellular component	integral component of membrane; endocytic vesicle membrane; clathrin-coated endocytic vesicle membrane; endosome; Golgi apparatus; trans-Golgi network membrane; endoplasmic reticulum membrane; membrane; late endosome membrane; Golgi membrane; plasma membrane; transport vesicle membrane; MHC class II protein complex; lysosomal membrane; endoplasmic reticulum; ER to Golgi transport vesicle membrane; lysosome; integral component of lumenal side of endoplasmic reticulum membrane; endosome membrane; external side of plasma membrane; cell surface; extracellular exosome;
Biological process	antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class II; immune system process; interferon-gamma-mediated signaling pathway; immunoglobulin production involved in immunoglobulin-mediated immune response; antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; humoral immune response mediated by circulating immunoglobulin; immune response; peptide antigen assembly with MHC class II protein complex; T cell receptor signaling pathway; adaptive immune response; negative regulation of interferon-gamma production; inflammatory response to antigenic stimulus; protein tetramerization; regulation of interleukin-4 production; negative regulation of T cell proliferation; T-helper 1 type immune response; positive regulation of insulin secretion involved in cellular response to glucose stimulus; T cell costimulation;
	Sources:Amigo / QuickGO
Orthologs
	3123
	n/a
ENSG00000236884; ENSG00000206240; ENSG00000229074; ENSG00000196126; ENSG00000206306;
	ENSG00000228080
	n/a
	P01911
	n/a
	NM_001243965; NM_002124; NM_001359193; NM_001359194
	n/a
	NP_001230894; NP_002115; NP_001346122; NP_001346123; NP_002115.2
	n/a
	Wikidata
View/Edit Human

HLA class II histocompatibility antigen, DRB1 beta chain is a protein that in humans is encoded by the HLA-DRB1 gene. DRB1 encodes the most prevalent beta subunit of HLA-DR. DRB1 alleles, especially those encoding amino acid sequence changes at positions 11 and 13, are associated risk of rheumatoid arthritis.

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