HLA-DR53
HLA-DR53 is an HLA-DR serotype that recognizes gene products of HLA-DRB4 locus. There are 13 alleles at this locus that encode 7 proteins.
major histocompatibility complex, class II, DR53 | ||
| Haplotypes | DRA*01:DRB4*0101 DRA*01:DRB4*0102 DRA*01:DRB4*0103 DRA*01:DRB4*0104 | |
| Structure (See HLA-DR) | ||
| Identifiers | alpha *0101 | |
| Symbol(s) | HLA-DRA | |
| EBI-HLA | DRA*0101 | |
| Identifiers | beta 4 *0101 *0102 *0103 *0104 | |
| Symbol(s) | HLA-DRB4 | |
| EBI-HLA | DRB4*0101 | |
| EBI-HLA | DRB4*0102 | |
| EBI-HLA | DRB4*0103 | |
| EBI-HLA | DRB4*0104 | |
| Shared data | ||
| Locus | chr.6 6p21.31 | |
DRB3, DRB4, and DRB5 are minor DR beta encoding loci, they have been recognized as having distinct evolution. and the DRB4 locus presence is linked to HLA-DR7 seropositivity. The DRB4*locus was apparently duplicated from an ancestor of the DRB1-DRB4 common locus around 5 million years ago.
DRB4 locus is only apparent in a small subset of DQ haplotypes, and most individuals lack DRB4. In addition the level of normal expression is 8 fold lower than the DRB1 in cells which can express both. and lowered because of both transcriptional and post-transcriptional regulation.
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