HLA-DQ5

HLA-DQ5 (DQ5) is a human leukocyte antigen serotype subgroup within HLA-DQ(DQ) serotypes. The serotype is determined by the antibody recognition of β5.x subset of DQ β-chains. The β-chain of DQ is encoded by HLA-DQB1 locus and DQ5 are encoded by the HLA-DQB1*05 allele group. This group currently contains 4 common alleles, DQB1*0501, *0502, *0503, and *0504. HLA-DQ5 and HLA-DQB1*05 are almost synonymous in meaning. DQ5 β-chains combine with α-chains, encoded by genetically linked HLA-DQA1 alleles, to form the cis-haplotype isoforms. These isoforms, are all HLA-DQ1 encoded by the DQA1*01 allele group.

HLA-DQ5
Illustration of HLA-DQ with gliadin peptide in the binding pocket.
Polymer typeMHC Class II, DQ cell surface antigen
Cis-haplotype Haplotype
isoform subtype DQA1 DQB1
DQ α1.1β5.1 DQ5.1 *0101 *0501
DQ α1.2β5.2 DQ5.2 *0102 *0502
DQ α1.4β5.3 DQ5.3 *0104 *0503
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