HLA-C

HLA-C
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	3BZF,%%s4NT6,%%s1EFX,%%s1IM9, 1QQD
Identifiers
Aliases	HLA-C, D6S204, HLA-JY3, HLC-C, PSORS1, major histocompatibility complex, class I, C, MHC
External IDs	OMIM: 142840 HomoloGene: 133080 GeneCards: HLA-C
Gene location (Human)
Chr.	Chromosome 6 (human)
End	31,272,130 bp
RNA expression pattern
	Top expressed in
	blood; ; right lung; ; spleen; ; right uterine tube; ; appendix; ; bone marrow; ; upper lobe of left lung; ; lymph node; ; bone marrow cells; ; monocyte;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptide antigen binding; protein binding;
Cellular component	integral component of membrane; phagocytic vesicle membrane; Golgi apparatus; early endosome membrane; membrane; Golgi membrane; plasma membrane; cell surface; endoplasmic reticulum; MHC class I protein complex; ER to Golgi transport vesicle membrane; integral component of lumenal side of endoplasmic reticulum membrane; extracellular exosome; secretory granule membrane; recycling endosome membrane;
Biological process	antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; immune system process; interferon-gamma-mediated signaling pathway; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; type I interferon signaling pathway; immune response; regulation of immune response; viral process; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	3107
	n/a
ENSG00000204525; ENSG00000233841; ENSG00000228299; ENSG00000225691; ENSG00000206435;
	ENSG00000237022; ENSG00000206452
	n/a
	P10321
	n/a
	NM_002117; NM_001243042
	n/a
	NP_001229971; NP_002108
	n/a
	Wikidata
View/Edit Human

HLA-C (Human Leukocyte Antigen-C) belongs to the MHC class I heavy chain receptors. The C receptor is a heterodimer consisting of a HLA-C mature gene product and β2-microglobulin. The mature C chain is anchored in the membrane. MHC Class I molecules, like HLA-C, are expressed in nearly all cells, and present small peptides to the immune system which surveys for non-self peptides.

HLA-C is a locus on chromosome 6, which encodes for many HLA-C alleles that are Class-I MHC receptors. HLA-C, localized proximal to the HLA-B locus, is located on the distal end of the HLA region. Most HLA-C:B haplotypes are in strong linkage disequilibrium and many are as ancient as the human species itself.

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