Huntingtin-interacting protein 1

HIP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2NO2, 2QA7, 3I00
Identifiers
Aliases	HIP1, HIP-I, ILWEQ, SHON, SHONbeta, SHONgamma, huntingtin interacting protein 1
External IDs	OMIM: 601767 MGI: 1099804 HomoloGene: 68463 GeneCards: HIP1
Gene location (Human)
Chr.	Chromosome 7 (human)
End	75,738,962 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	135,545,120 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; sural nerve; ; inferior ganglion of vagus nerve; ; renal medulla; ; Achilles tendon; ; subthalamic nucleus; ; lower lobe of lung; ; popliteal artery; ; right coronary artery; ; visceral pleura;
	Top expressed in
	saccule; ; ascending aorta; ; trigeminal ganglion; ; aortic valve; ; external carotid artery; ; internal carotid artery; ; lens; ; otic placode; ; interventricular septum; ; blastocyst;
	More reference expression data
	n/a
Gene ontology
Molecular function	clathrin binding; structural constituent of cytoskeleton; protein binding; phosphatidylinositol binding; actin binding; phospholipid binding; epidermal growth factor receptor binding; phosphatidylinositol-4,5-bisphosphate binding; clathrin light chain binding; phosphatidylinositol-3-phosphate binding; glutamate receptor binding; AP-2 adaptor complex binding; clathrin adaptor activity; protein homodimerization activity; phosphatidylinositol-3,4-bisphosphate binding; protein heterodimerization activity; actin filament binding; phosphatidylinositol-3,5-bisphosphate binding;
Cellular component	cytoplasm; Golgi apparatus; membrane; intracellular membrane-bounded organelle; clathrin-coated vesicle membrane; cytoskeleton; cytoplasmic vesicle; endomembrane system; clathrin-coated vesicle; nucleus; cytosol; AP-2 adaptor complex; extrinsic component of cytoplasmic side of plasma membrane; extrinsic component of presynaptic membrane; extrinsic component of postsynaptic membrane; presynapse; postsynapse; postsynaptic membrane; glutamatergic synapse; actin cortical patch;
Biological process	regulation of apoptotic process; cell differentiation; positive regulation of receptor-mediated endocytosis; regulation of transcription, DNA-templated; endocytosis; transcription, DNA-templated; clathrin-dependent endocytosis; clathrin coat assembly; apoptotic signaling pathway; activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic process; cytoskeleton organization; regulation of endocytosis; positive regulation of epidermal growth factor receptor signaling pathway; protein stabilization; positive regulation of protein kinase B signaling; membrane organization; neurotransmitter receptor transport; positive regulation of platelet-derived growth factor receptor-beta signaling pathway; actin filament organization;
	Sources:Amigo / QuickGO
Orthologs
	3092
	215114
	ENSG00000127946
	ENSMUSG00000039959
	O00291
	Q8VD75
	NM_001243198; NM_005338; NM_001382444; NM_001382445
	NM_146001; NM_001382848
	NP_001230127; NP_005329; NP_001369373; NP_001369374
	NP_666113; NP_001369777
	Wikidata
View/Edit Human	View/Edit Mouse

Huntingtin-interacting protein 1 also known as HIP-1 is a protein that in humans is encoded by the HIP1 gene.

Hip-1 is a protein that interacts with the huntingtin protein. It is known to contain a domain homologous to the death effector domains (DED) found on proteins involved in apoptosis. It is believed that accumulation of high levels of the free form of this protein (free as in dissociated from the huntingtin and free to bind other key protein(s)) in the cell is one of the mechanisms by which neuron cell death is caused in Huntington's disease (via the caspase-3 route). The role of Hip-1 in caspase mediated cell death remains unclear.

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