Hypoxia-inducible factor
Hypoxia-inducible factors (HIFs) are transcription factors that respond to decreases in available oxygen in the cellular environment, or hypoxia. They also respond to instances of pseudohypoxia, such as thiamine deficiency. Both hypoxia and pseudohypoxia leads to impairment of adenosine triphosphate (ATP) production by the mitochondria.
| hypoxia-inducible factor 1, alpha subunit | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | HIF1A | ||||||
| NCBI gene | 3091 | ||||||
| HGNC | 4910 | ||||||
| OMIM | 603348 | ||||||
| RefSeq | NM_001530 | ||||||
| UniProt | Q16665 | ||||||
| Other data | |||||||
| Locus | Chr. 14 q21-q24 | ||||||
| |||||||
| aryl hydrocarbon receptor nuclear translocator | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | ARNT | ||||||
| Alt. symbols | HIF1B, bHLHe2 | ||||||
| NCBI gene | 405 | ||||||
| HGNC | 700 | ||||||
| OMIM | 126110 | ||||||
| RefSeq | NM_001668 | ||||||
| UniProt | P27540 | ||||||
| Other data | |||||||
| Locus | Chr. 1 q21 | ||||||
| |||||||
| endothelial PAS domain protein 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | EPAS1 | ||||||
| Alt. symbols | HIF2A, MOP2, PASD2, HLF | ||||||
| NCBI gene | 2034 | ||||||
| HGNC | 3374 | ||||||
| OMIM | 603349 | ||||||
| RefSeq | NM_001430 | ||||||
| UniProt | Q99814 | ||||||
| Other data | |||||||
| Locus | Chr. 2 p21-p16 | ||||||
| |||||||
| aryl-hydrocarbon receptor nuclear translocator 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | ARNT2 | ||||||
| Alt. symbols | HIF2B, KIAA0307, bHLHe1 | ||||||
| NCBI gene | 9915 | ||||||
| HGNC | 16876 | ||||||
| OMIM | 606036 | ||||||
| RefSeq | NM_014862 | ||||||
| UniProt | Q9HBZ2 | ||||||
| Other data | |||||||
| Locus | Chr. 1 q24 | ||||||
| |||||||
| hypoxia-inducible factor 3, alpha subunit | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | HIF3A | ||||||
| NCBI gene | 64344 | ||||||
| HGNC | 15825 | ||||||
| OMIM | 609976 | ||||||
| RefSeq | NM_152794 | ||||||
| UniProt | Q9Y2N7 | ||||||
| Other data | |||||||
| Locus | Chr. 19 q13 | ||||||
| |||||||
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