Hydroxycarboxylic acid receptor 3

HCAR3
Identifiers
Aliases	HCAR3, GPR109B, HCA3, HM74, PUMAG, Puma-g, Niacin receptor 2, hydroxycarboxylic acid receptor 3
External IDs	OMIM: 606039 HomoloGene: 130547 GeneCards: HCAR3
Gene location (Human)
Chr.	Chromosome 12 (human)
End	122,716,811 bp
RNA expression pattern
	Top expressed in
	blood; ; spleen; ; monocyte; ; bone marrow; ; skin of abdomen; ; appendix; ; bone marrow cells; ; placenta; ; upper lobe of left lung; ; subcutaneous adipose tissue;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity;
Cellular component	integral component of membrane; cell junction; plasma membrane; integral component of plasma membrane; membrane;
Biological process	G protein-coupled receptor signaling pathway; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	8843
	n/a
	ENSG00000255398
	n/a
	P49019
	n/a
	NM_006018
	n/a
	NP_006009
	n/a
	Wikidata
View/Edit Human

Hydroxycarboxylic acid receptor 3 (HCA₃), also known as niacin receptor 2 (NIACR2) and GPR109B, is a protein which in humans is encoded by the HCAR3 gene. HCA₃, like the other hydroxycarboxylic acid receptors HCA₁ and HCA₂, is a G_i/o-coupled G protein-coupled receptor (GPCR). The primary endogenous agonists of HCA₃ are 3-hydroxyoctanoic acid and kynurenic acid. HCA₃ is also a low-affinity biomolecular target for niacin (aka nicotinic acid).

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