Guaifenesin

Guaifenesin
Clinical data
Pronunciation	/ɡwaɪˈfɛnɪsɪn/
Trade names	Mucinex, others
Other names	Glyceryl guaiacolate
AHFS/Drugs.com	Monograph
MedlinePlus	a682494
License data	US DailyMed: Guaifenesin;
Routes of; administration	By mouth
ATC code	R05CA03 (WHO) QM03BX90 (WHO);
Legal status
Legal status	US: WARNINGOTC / Rx-only;
Pharmacokinetic data
Metabolism	Kidney
Elimination half-life	1–5 hours
Identifiers
	IUPAC name (RS)-3-(2-methoxyphenoxy)propane-1,2-diol;
CAS Number	93-14-1 ;
PubChem CID	3516;
IUPHAR/BPS	7617;
DrugBank	DB00874 ;
ChemSpider	3396 ;
UNII	495W7451VQ;
KEGG	D00337 ;
ChEMBL	ChEMBL980 ;
CompTox Dashboard (EPA)	DTXSID5023114 ;
ECHA InfoCard	100.002.021
Chemical and physical data
Formula	C10H14O4
Molar mass	198.218 g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	SMILES O(c1ccccc1OC)CC(O)CO;
	InChI InChI=1S/C10H14O4/c1-13-9-4-2-3-5-10(9)14-7-8(12)6-11/h2-5,8,11-12H,6-7H2,1H3 ; Key:HSRJKNPTNIJEKV-UHFFFAOYSA-N ;
	(verify)

Guaifenesin, also known as glyceryl guaiacolate, is an expectorant medication taken by mouth and marketed as an aid to eliminate sputum from the respiratory tract. Chemically, it is an ether of guaiacol and glycerine. It may be used in combination with other medications. A 2014 study found that guaifenesin has no effect on sputum production or clearance in upper respiratory infections.

Side effects may include dizziness, sleepiness, skin rash, and nausea. While it has not been properly studied in pregnancy, it appears to be safe. It is believed to work by making airway secretions more liquid.

Guaifenesin has been used medically since at least 1933. It is available as a generic medication and over the counter. In 2021, it was the 288th most commonly prescribed medication in the United States, with more than 600,000 prescriptions.

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