Gray platelet syndrome
Gray platelet syndrome (GPS), or platelet alpha-granule deficiency, is a rare congenital autosomal recessive bleeding disorder caused by a reduction or absence of alpha-granules in blood platelets, and the release of proteins normally contained in these granules into the marrow, causing myelofibrosis. The name derives from the initial observation of gray appearance of platelets with a paucity of granules on blood films from a patient with a lifelong bleeding disorder.
| Gray platelet syndrome | |
|---|---|
| Other names | Platelet alpha-granule deficiency |
| Gray platelet syndrome is inherited in an autosomal recessive manner. | |
| Specialty | Hematology |
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