Glutamyl-tRNA reductase
A glutamyl-tRNA reductase (EC 1.2.1.70) is an enzyme that catalyzes the chemical reaction
- L-glutamate 1-semialdehyde + NADP+ + tRNAGlu L-glutamyl-tRNAGlu + NADPH + H+
| glutamyl-tRNA reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.2.1.70 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The 3 substrates of this enzyme are L-glutamate 1-semialdehyde, NADP+, and tRNA(Glu), whereas its 3 products are L-glutamyl-tRNA(Glu), NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, to be specific, those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-glutamate-semialdehyde: NADP+ oxidoreductase (L-glutamyl-tRNAGlu-forming). This enzyme participates in porphyrin and chlorophyll metabolism.
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