Glutamate dehydrogenase 1

GLUD1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1L1F, 1NR1
Identifiers
Aliases	GLUD1, GDH, GDH1, GLUD, glutamate dehydrogenase 1, hGDH1
External IDs	OMIM: 138130 MGI: 95753 HomoloGene: 55885 GeneCards: GLUD1
Gene location (Human)
Chr.	Chromosome 10 (human)
End	87,094,843 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	34,067,222 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; superior vestibular nucleus; ; nucleus accumbens; ; amygdala; ; caudate nucleus; ; corpus callosum; ; external globus pallidus; ; subthalamic nucleus; ; putamen; ; hypothalamus;
	Top expressed in
	left lobe of liver; ; medial vestibular nucleus; ; dorsal tegmental nucleus; ; mammillary body; ; globus pallidus; ; ventral tegmental area; ; paraventricular nucleus of hypothalamus; ; lateral hypothalamus; ; ventromedial nucleus; ; medial geniculate nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; ADP binding; GTP binding; leucine binding; protein binding; NAD+ binding; identical protein binding; oxidoreductase activity; ATP binding; glutamate dehydrogenase [NAD(P)+ activity]; glutamate dehydrogenase (NAD+) activity; oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor;
Cellular component	cytoplasm; mitochondrial matrix; mitochondrion;
Biological process	glutamate catabolic process; glutamate biosynthetic process; substantia nigra development; cellular amino acid metabolic process; cellular amino acid biosynthetic process; glutamine metabolic process; tricarboxylic acid metabolic process; positive regulation of insulin secretion; mitochondrion organization;
	Sources:Amigo / QuickGO
Orthologs
	2746
	14661
	ENSG00000148672
	ENSMUSG00000021794
	P00367
	P26443
NM_005271; NM_001318900; NM_001318901; NM_001318902; NM_001318904;
	NM_001318905; NM_001318906
	NM_008133
NP_001305829; NP_001305830; NP_001305831; NP_001305833; NP_001305834;
	NP_001305835; NP_005262
	NP_032159
	Wikidata
View/Edit Human	View/Edit Mouse

GLUD1 (glutamate dehydrogenase 1) is a mitochondrial matrix enzyme, one of the family of glutamate dehydrogenases that are ubiquitous in life, with a key role in nitrogen and glutamate (Glu) metabolism and energy homeostasis. This dehydrogenase is expressed at high levels in liver, brain, pancreas and kidney, but not in muscle. In the pancreatic cells, GLUD1 is thought to be involved in insulin secretion mechanisms. In nervous tissue, where glutamate is present in concentrations higher than in the other tissues, GLUD1 appears to function in both the synthesis and the catabolism of glutamate and perhaps in ammonia detoxification.

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