Glucagon-like peptide-1 receptor

GLP1R
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3C59, 3C5T, 3IOL, 4ZGM
Identifiers
Aliases	GLP1R, glucagon-like peptide 1 receptor, GLP-1, GLP-1-R, GLP-1R, glucagon like peptide 1 receptor
External IDs	OMIM: 138032 MGI: 99571 HomoloGene: 1558 GeneCards: GLP1R
Gene location (Human)
Chr.	Chromosome 6 (human)
End	39,091,303 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	31,159,765 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; sperm; ; vena cava; ; body of pancreas; ; oocyte; ; periodontal fiber; ; secondary oocyte; ; cardia; ; medulla oblongata; ; pons;
	Top expressed in
	islet of Langerhans; ; supraoptic nucleus; ; left lung lobe; ; right lung lobe; ; pontine nuclei; ; duodenum; ; epithelium of stomach; ; yolk sac; ; arcuate nucleus; ; paraventricular nucleus of hypothalamus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	G protein-coupled peptide receptor activity; G protein-coupled receptor activity; signal transducer activity; protein binding; glucagon receptor activity; transmembrane signaling receptor activity; glucagon-like peptide 1 receptor activity; peptide hormone binding;
Cellular component	integral component of membrane; membrane; plasma membrane; intracellular anatomical structure; integral component of plasma membrane;
Biological process	regulation of heart contraction; regulation of insulin secretion; positive regulation of cytosolic calcium ion concentration; cellular response to glucagon stimulus; activation of adenylate cyclase activity; cell surface receptor signaling pathway; positive regulation of blood pressure; learning or memory; cAMP-mediated signaling; signal transduction; adenylate cyclase-activating G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway; response to psychosocial stress;
	Sources:Amigo / QuickGO
Orthologs
	2740
	14652
	ENSG00000112164
	ENSMUSG00000024027
	P43220
	O35659
	NM_002062
	NM_021332
	NP_002053
	NP_067307
	Wikidata
View/Edit Human	View/Edit Mouse

The glucagon-like peptide-1 receptor (GLP1R) is a G protein-coupled receptor (GPCR) found on beta cells of the pancreas and on neurons of the brain. It is involved in the control of blood sugar level by enhancing insulin secretion. In humans it is synthesised by the gene GLP1R, which is present on chromosome 6. It is a member of the glucagon receptor family of GPCRs. GLP1R is composed of two domains, one extracellular (ECD) that binds the C-terminal helix of GLP-1, and one transmembrane (TMD) domain that binds the N-terminal region of GLP-1. In the TMD domain there is a fulcrum of polar residues that regulates the biased signaling of the receptor while the transmembrane helical boundaries and extracellular surface are a trigger for biased agonism.

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