Givinostat

Givinostat
Clinical data
Trade names	Duvyzat
License data	US DailyMed: Givinostat;
Routes of; administration	By mouth
ATC code	M09AX14 (WHO) ;
Legal status
Legal status	US: ℞-only;
Identifiers
	IUPAC name {6-[(diethylamino)methyl]naphthalen-2-yl}methyl [4-(hydroxycarbamoyl)phenyl]carbamate;
CAS Number	497833-27-9 ;
PubChem CID	9804992;
IUPHAR/BPS	7490;
DrugBank	DB12645;
ChemSpider	7980752 ;
UNII	5P60F84FBH;
KEGG	D12742;
ChEBI	CHEBI:94187;
ChEMBL	ChEMBL1213492;
PDB ligand	QCM (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID70198049 ;
ECHA InfoCard	100.258.524
Chemical and physical data
Formula	C24H27N3O4
Molar mass	421.497 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCc2cc1ccc(cc1cc2)CN(CC)CC)Nc3ccc(cc3)C(=O)NO;
	InChI InChI=1S/C24H27N3O4/c1-3-27(4-2)15-17-5-7-21-14-18(6-8-20(21)13-17)16-31-24(29)25-22-11-9-19(10-12-22)23(28)26-30/h5-14,30H,3-4,15-16H2,1-2H3,(H,25,29)(H,26,28) ; Key:YALNUENQHAQXEA-UHFFFAOYSA-N ;
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Givinostat, sold under the brand name Duvyzat is a medication used for the treatment of Duchenne muscular dystrophy. It is a histone deacetylase inhibitor with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities. It is a histone deacetylase (HDAC) inhibitor that works by targeting pathogenic processes to reduce inflammation and loss of muscle.

The most common side effects include diarrhea, abdominal pain, a decrease in platelets—which can lead to increased bleeding—nausea/vomiting, an increase in triglycerides (a type of fat in the body) and fever.

Givinostat was approved for medical use in the United States in March 2024. Givinostat is the first nonsteroidal medication approved by the FDA to treat people with all genetic variants of Duchenne Muscular Dystrophy.

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