Gewald reaction
The Gewald reaction is an organic reaction involving the condensation of a ketone (or aldehyde when R2 = H) with a α-cyanoester in the presence of elemental sulfur and base to give a poly-substituted 2-amino-thiophene.
| Gewald reaction | |
|---|---|
| Named after | Karl Gewald |
| Reaction type | Ring forming reaction |
| Identifiers | |
| Organic Chemistry Portal | gewald-reaction |
The reaction is named after the German chemist Karl Gewald (born 1930).
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