Gastrin-releasing peptide receptor

GRPR
Identifiers
Aliases	GRPR, BB2, gastrin releasing peptide receptor, BB2R, BRS2
External IDs	OMIM: 305670 MGI: 95836 HomoloGene: 21098 GeneCards: GRPR
Gene location (Human)
Chr.	X chromosome (human)
End	16,153,518 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	162,332,673 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; pancreatic ductal cell; ; stromal cell of endometrium; ; deltoid muscle; ; gastric mucosa; ; smooth muscle tissue; ; monocyte; ; islet of Langerhans; ; sigmoid colon; ; prefrontal cortex;
	Top expressed in
	supraoptic nucleus; ; ankle joint; ; suprachiasmatic nucleus; ; right ventricle; ; vastus lateralis muscle; ; adrenal gland; ; large intestine; ; colon; ; hippocampus proper; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; G protein-coupled receptor activity; G protein-coupled peptide receptor activity; neuropeptide receptor activity; neuropeptide binding;
Cellular component	membrane; integral component of membrane; plasma membrane; integral component of plasma membrane;
Biological process	regulation of cell population proliferation; signal transduction; cell population proliferation; G protein-coupled receptor signaling pathway; psychomotor behavior; response to external biotic stimulus; phospholipase C-activating G protein-coupled receptor signaling pathway; neuropeptide signaling pathway; social behavior; motor behavior; learning or memory;
	Sources:Amigo / QuickGO
Orthologs
	2925
	14829
	ENSG00000126010
	ENSMUSG00000031364
	P30550
	P21729
	NM_005314
	NM_008177
	NP_005305; NP_005305.1
	NP_032203
	Wikidata
View/Edit Human	View/Edit Mouse

The gastrin-releasing peptide receptor (GRPR), now properly known as BB₂ is a G protein-coupled receptor whose endogenous ligand is gastrin releasing peptide. In humans it is highly expressed in the pancreas and is also expressed in the stomach, adrenal cortex and brain.

Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.

The transcription factor CREB is a regulator of human GRP-R expression in colon cancer.

Activation MOR1D‐GRPR heteromers in the spinal cord mediate the common troublesome opioid-induced itch.

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